Machine description

Multi-process laboratory skid: FAME (Fluid Assisted Micro-Encapsulation) and SAS (Supercritical AntiSolvent). This skid allows atomization thanks to the properties of supercritical CO2. It is mainly composed of :

• Two high pressure autoclaves
  A CO2 pump
  A co-solvent pump
  A compressor
  A chiller
  A hot bath
  A spillway

Principle and operation

SAS (Supercritical AntiSolvent) : Consists of solubilising the material in an organic solvent, then contacting the solution thus formed with a supercritical fluid (usually CO2). This phenomenon will lead to the precipitation or recrystallization of the material, which will then take the form of a fine powder.

The supercritical fluid appears as an anti-solvent. This process is called SAS, for Supercritical Anti-Solvent.

FAME (Fluid Assisted Micro Encapsulation) : Consists of solubilizing supercritical CO2 in a material to saturation. This mixture is then depressurized and expanded.